Measurement of Exercise Tolerance Before Surgery (METS) Study

Team Members
  • Dr. Duminda Wijeysundera - St. Michael's Hospital, University of Toronto
  • Dr. Brian Cuthbertson - Sunnybrook Health Sciences Centre, University of Toronto

This Canadian-led multicentre prospective cohort study aims to identify the optimal approach for assessing patients’ physical fitness for major non-cardiac surgery. The METS Study will recruit 1312 adults to first compare the current clinical approach (subjective assessment) against the “gold-standard” measure of exercise capacity – cardiopulmonary exercise testing (CPET) – for predicting postoperative major cardiac complications and death. These measures will then be compared to 2 less costly alternatives to CPET: the Duke Activity Status Index (DASI) questionnaire and a blood test (plasma NT pro-BNP concentration). The researchers will also develop a staged risk stratification algorithm.